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Alloantigen recognition
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Alloantigen recognition : ウィキペディア英語版
Alloantigen recognition
Direct and indirect alloantigen recognition are two mechanisms by which T cells may recognize alloantigens and lead to transplant rejection after an organ transplant.
==Direct alloantigen recognition==
Donor tissue dendritic cells 〔Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3864–8.〕 migrate to lymph nodes, stimulating a measurable percentage of recipient T cells. The host T cells in the lymph node recognize either the allograft HLA or an associated bound peptide.
In this case, alloreactive T cells are stimulated by donor APCs which express both the allogeneic MHC and costimulatory activity.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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